SERVERNAME: frsvr_SDP TARGET: T0057 PARAMETERS: excludefolds: 1kja 1hli include h3p2 URL: http://www.cs.bgu.ac.il/~dfischer/cafasp1/frsvr_SDP.t0057 SERVER'S URL: http://www.doe-mbi.ucla.edu/people/frsvr/submit.html RANK FOLD SCORE LENGTH_ALIGNMENT SEQ_ID% 1 1gd1o 8.02 295 21 2 1moq 4.99 322 16 3 1dapa 4.28 276 22 4 1xgsa 4.13 269 19 5 1npx 3.83 324 22 6 3kar 3.76 281 16 7 1btma 3.75 238 19 8 4mdha 3.54 271 18 9 1hlpa 3.51 269 19 10 1llda 3.25 284 20 END NOTICE: the excludefolds excludes 2 library entries which are models. The server's output is: The three-dimensional fold predicted for your amino acid sequence is in the table below. HERE I INCLUDE ONLY THE RESULTS OF THE gonnet+predss METHOD. THE OTHER RESULTS CAN BE FOUND AT THE URL (www page) SPECIFIED AT THE END OF THIS MESSAGE. Please cite: Fischer, D. and Eisenberg, D. Fold Recognition Using Sequence-Derived Predictions. Protein Science, 5, 947-955, 1996. * * * * N O T E * * * * PLEASE CONSULT ALSO THE RESULTS OF gonnet+predss+multi Your sequence was translated to: seq.seq Length: 340 December 21, 1998 05:24 Type: P Check: 8932 .. 1 MINVAVNGYG TIGKRVADAI IKQPDMKLVG VAKTSPNYEA FIAHRRGIRI 51 YVPQQSIKKF EESGIPVAGT VEDLIKTSDI VVDTTPNGVG AQYKPIYLQL 101 QRNAIFQGGE KAEVADISFS ALCNYNEALG KKYIRVVSCN TTALLRTICT 151 VNKVSKVEKV RATIVRRAAD QKEVKKGPIN SLVPDPATVP SHHAKDVNSV 201 IRNLDIATMA VIAPTTLMHM HFINITLKDK VEKKDILSVL ENTPRIVLIS 251 SKYDAEATAE LVEVARDLKR DRNDIPEVMI FSDSIYVKDD EVMLMYAVHQ 301 ESIVVPENID AIRASMKLMS AEDSMRITNE SLGILKGYLI NAME: t0057 FROM: dfischer@indigo.cs.bgu.ac.il BY YOUR REQUEST I HAVE NOT USED THE FOLLOWING FOLDS: 1hli 1kja The method used for this prediction was: gonnet+predss . Most similar fold: 1gd1o $HOLO-*D-*GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENAS 2 (E.C.1.2.1.12) RANK Z-SCORE FOLD LENGTHALI %ID 1 8.02 1gd1o 295 21 [MULTIDOMAIN ] 99--3-15--4-34 [(a/b) ; NAD(P)-binding Rossmann-fold domains] [ (a+b) ; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain] 3-15-1-3-1-2-1-1 RC:, 2 4.99 1moq 322 16 998 3 4.28 1dapa 276 22 1997 new ; C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH N ] 4 4.13 1xgsa 269 19 1997 new ; METHIONINE AMINOPEPTIDASE FROM HYPERTHERMOPHILE P ] 5 3.83 1npx 324 22 99--3-4--3-4--4-38 MULTIDOMAIN ; ] [(a/b) ; FAD (also NAD)-binding motif] [(a/b) ; FAD (also NAD)-binding motif] [ (a+b) ; FAD/NAD-linked reductases, dimerisation (C-terminal) domain] 3-4-1-3-3-1-1-1 R, 6 3.76 3kar 281 16 998 7 3.75 1btma 238 19 3-1 a/b ; beta/alpha (TIM)-barrel] 3-1-10-1-1-7-1-1 8 3.54 4mdha 271 18 99--3-15--4-74 a/b ; NAD(P)-binding Rossmann-fold domains] [(a+b) ; Lactate & malate dehydrogenases, C-terminal domain] [MULTIDOMAIN ; ] 99--3-15--4-74 [(a/b) ; NAD(P)-binding Rossmann-fold domains] [ (a+b) ; Lactate & malate dehydrogenases, C-terminal domain] 9 3.51 1hlpa 269 19 99--3-15--4-74 a/b ; NAD(P)-binding Rossmann-fold domains] [(a+b) ; Lactate & malate dehydrogenases, C-terminal domain] [MULTIDOMAIN ; ] 99--3-15--4-74 [(a/b) ; NAD(P)-binding Rossmann-fold domains] [ (a+b) ; Lactate & malate dehydrogenases, C-terminal domain] 10 3.25 1llda 284 20 99--3-15--4-74 a/b ; NAD(P)-binding Rossmann-fold domains] [(a+b) ; Lactate & malate dehydrogenases, C-terminal domain] [MULTIDOMAIN ; ] 99--3-15--4-74 [(a/b) ; NAD(P)-binding Rossmann-fold domains] [ (a+b) ; Lactate & malate dehydrogenases, C-terminal domain] 11 3.23 1gd1o_0-333 155 21 3-15 a/b ; NAD(P)-binding Rossmann-fold domains] 3-15-1-3-1-2-1-1 RC:, 12 3.21 1lla_2-379 276 21 1-49 alpha ; Hemocyanin, N-terminal and middle domains] 1-49-1-1-1-1-1-1 13 3.13 1ral 276 22 3-1 a/b ; beta/alpha (TIM)-barrel] 3-1-4-1-2-1-1 14 3.11 1nipb 271 18 3-21 a/b ; P-loop n. tri. hydrolases] 3-21-1-3-3-1-1-2 15 3.04 1cyda 188 23 1997 new ; CARBONYL REDUCTASE COMPLEXED WITH NADPH AND 2-PROPAN] LEGEND: COL. 1: RANK. The ranks are obtained by sorting the fold library, by Z-SCORES, in decreasing order. Only the 15 structures that are most compatible to your sequence are shown. COL. 2: Z-SCORE. The z-scores are computed using the distribution of raw scores (not shown) of all folds. COL. 3: FOLD. Protein Data Bank codes for the coordinates of the 3D structures. COL. 4: LENGTHALI. The number of residues from your sequence that were aligned to the fold. COL. 5: % ID. Percentage of identical residues in the alignment. RELIABILITY OF THIS PREDICTION: With this method the confidence threshold is a z-score of 4.8 +- 1.0. YOUR HIGHEST SCORING FOLD IS ABOVE THIS THRESHOLD Below is the alignment of your sequence with the top hit structure. In the near future, all the alignments in a more readable format will be made available. bbbbb hhhhhhhhhh bbbbbb hhhhhhhhhh MINVAVNGYGTIGKRVADAIIKQPDMKLVGVAK.TSPNYEAFIAHRRGIR | || | || | | | || | | | | | AVKVGINGFGRIGRNVFRAALKNPDIEVVAVNDLTDANTLAHLLKYDSVH bbbbbb hhhhhhhhhh bbbbbbb hhhhhhhhhbb bb hhhhhhhhh b hhhhhh bbbb IYVPQQSIKKFEESGIPVAGTVEDLIKTS.............DIVVDTTP | | | | |||| | GRLDAEV..SVNGNNLVVNGK.EIIVKAERDPENLAWGEIGVDIVVESTG bb b bbb bbbb b bbbbb hhh hhhh bbbb hhhh bbb bbbbbbb hhh hh bb NGVGAQYKPIYLQLQRNAIFQGGEKAEVADISFSALCNYNE.ALGKKYIR | | || | | RFTKREDAAKHLEAGAKKVIISAPANE..DITIVMGVNQDKYDKAHHVIS hhhh hhhh bbbb bb hhh bbb bbb bbbbhhhhhh bbbb VVSCNTTALLRTICTVNKVSKVEKVRATIVRRAADQKEVKKGPINSLVPD || | | | | | | NASCTTNCLAPFAKVLHEQFGIVRGMMTTVHSYTNDQRILDLPHKDLRRA hhhhhhhhhhhhhhhhh bbbbbbbbbbb bbbbb bbbbbb bbbbb bbbbbb PATVPS......HHAKDVNSVIRNL..DIATMAVIAPTTLMHMHFINITL | | || | | | || || | RAAAESIIPTTTGAAKAVALVLPELKGKLNGMAMRVPTPNVSVVDLVAEL bbbb hhhhh hhh bbbbbbbb bbbbbbbbb hhhhhhhh KDKVEKKDILSVLE | | EKEVTVEEVNAALK hhhhhhhhh 22% Additional information for your prediction can be found at the url: http://www.doe-mbi.ucla.edu/people/frsvr/preds/24397t0057/24397t0057.html p.s. if you need further information on this output, send an e-mail message to: fischer@mbi.ucla.edu