November 9, Tuesday
12:00 – 13:30
Gene Translation - Computational Modeling and Systems Biology
Computer Science seminar
Lecturer : Tamir Tuller
Affiliation : Weizmann Institute of Science
Location : 202/37
Host : Dr. Michal Ziv Ukelson
Gene Translation (GT) is the complex process of decoding the mRNA sequences by the ribosome to produce proteins. The rapid accumulation of genomic data and large scale measurements that are related to GT (e.g. sequencing of genomes and measurements of gene expression, protein abundance, and ribosome densities) enables developing computational models and performing large scale systems biological study of this biological process.In this talk, I will survey our recent results in understanding and modeling GT.Specifically, I will
describe: (1) a novel systems biological analysis of the dynamic of ribosome movement based on the different features mRNA sequences, a key to understanding GT. (2) A computationally efficient predictive model of GT that is based on the physical and dynamic nature of this process.
The talk is self-contained and requires no prior knowledge in Biology.