Ben Gurion University of the Negev

Department of Computer Science

 

MultiRNAMute: RNA Secondary Structure Mutation Analysis Tool for Multiple Point Mutations.




MultiRNAMute is an application extension to RNAMute that provides a user friendly interface for analyzing the effects of multiple point mutations on RNA secondary structure.

As with proteins, mutations in RNAs have potential to alter functionality in important biological processes. Predictions of selective mutations can be performed based on the assumption that structure relates to function. Detecting mutations with desired structural effects among all possible multiple point mutations may therefore be valuable and can be tested experimentally.

Currently, MultiRNAMute is available on a Linux platform.

 click here to download

- Extract the file with the commands:
1. >gunzip MultiRNAMute.tar.gz
2. >tar xvf MultiRNAMute.tar

More details on how to run the program are available here.



Reference: Churkin A, Barash D. An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptimal folding solutions. BMC Bioinformatics, 9(1):222, April 2008.

Comments and inquiries should be sent to: dbarash@cs.bgu.ac.il